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Cellular Processes: Some preclinical studies have examined biological mechanisms in laboratory and animal research settings

NeuroToxicology 30 (2009) 761765

Commun Biol 8 , 15 (2025)

Notably, lactate accumulation reprograms macrophage bioenergetic pathways and drives their functional repolarization from pro-inflammatory to reparative phenotypes through shifts in intracellular metabolite availability (67)